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Pretransplant Cardiac Evaluation Using Novel Technology.

Mohamad Hemu1, Allison Zimmerman2, Dinesh Kalra3

  • 1Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA. mohamad_r_hemu@rush.edu.

Journal of Clinical Medicine
|May 19, 2019
PubMed
Summary

Hematopoietic stem-cell transplantation (HSCT) carries cardiovascular risks. Pre-transplant cardiac screening with advanced imaging can identify high-risk patients, improving outcomes and reducing mortality.

Keywords:
cardiac imagingcardiac magnetic resonancecardiovascular complicationscoronary computed tomographyechocardiogramhematopoietic stem cell transplantspeckle tracking echocardiography

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Area of Science:

  • Cardiology
  • Hematology
  • Oncology

Background:

  • Hematopoietic stem-cell transplantation (HSCT) is a vital treatment for various cancers and blood disorders.
  • Cardiovascular complications, including heart failure and arrhythmias, are significant risks post-HSCT.
  • Effective pre-transplant cardiac risk stratification is crucial for patient safety.

Purpose of the Study:

  • To review the role of cardiac screening in the pre-HSCT phase.
  • To explore the utility of novel imaging technologies for pre-transplant cardiac assessment.
  • To improve patient selection and reduce adverse cardiovascular events after HSCT.

Main Methods:

  • Review of current literature on pre-HSCT cardiac evaluation.
  • Discussion of advanced cardiac imaging modalities (e.g., cardiac MRI, CT, echocardiography).
  • Analysis of risk factors and predictive values of different screening tests.

Main Results:

  • Cardiovascular complications are a leading cause of morbidity and mortality post-HSCT.
  • Novel imaging techniques offer enhanced detection of subclinical cardiac dysfunction.
  • Early identification of high-risk patients allows for tailored management strategies.

Conclusions:

  • Pre-HSCT cardiac screening is essential for optimizing patient outcomes.
  • Advanced cardiac imaging plays a pivotal role in risk stratification before transplantation.
  • Implementing comprehensive cardiac screening protocols can mitigate life-threatening complications.