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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
Pretransplant Cardiac Evaluation Using Novel Technology
Mohamad Hemu1, Allison Zimmerman2, Dinesh Kalra3
1Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA. mohamad_r_hemu@rush.edu.
Insights
Hematopoietic stem-cell transplantation (HSCT) carries cardiovascular risks. Pre-transplant cardiac screening with advanced imaging can identify high-risk patients, improving outcomes and reducing mortality.
Area of Science:
- Cardiology
- Hematology
- Oncology
Background:
- Hematopoietic stem-cell transplantation (HSCT) is a vital treatment for various cancers and blood disorders.
- Cardiovascular complications, including heart failure and arrhythmias, are significant risks post-HSCT.
- Effective pre-transplant cardiac risk stratification is crucial for patient safety.
Purpose of the Study:
- To review the role of cardiac screening in the pre-HSCT phase.
- To explore the utility of novel imaging technologies for pre-transplant cardiac assessment.
- To improve patient selection and reduce adverse cardiovascular events after HSCT.
Main Methods:
- Review of current literature on pre-HSCT cardiac evaluation.
- Discussion of advanced cardiac imaging modalities (e.g., cardiac MRI, CT, echocardiography).
- Analysis of risk factors and predictive values of different screening tests.
Main Results:
- Cardiovascular complications are a leading cause of morbidity and mortality post-HSCT.
- Novel imaging techniques offer enhanced detection of subclinical cardiac dysfunction.
- Early identification of high-risk patients allows for tailored management strategies.
Conclusions:
- Pre-HSCT cardiac screening is essential for optimizing patient outcomes.
- Advanced cardiac imaging plays a pivotal role in risk stratification before transplantation.
- Implementing comprehensive cardiac screening protocols can mitigate life-threatening complications.
Abstract:
Hematopoietic stem-cell transplantation (HSCT) is a complex procedure that has been increasingly successful in treating malignant and nonmalignant conditions. Despite its effectiveness, it can be associated with potentially life-threatening adverse effects. New onset heart failure, ischemic disease, and arrhythmias are among the most notable cardiovascular complications post-HSCT. As a result, appropriate cardiac risk stratification prior to transplant could result in decreased morbidity and mortality by identifying patients with a higher probability of tolerating possible toxicities associated with HSCT. In this review, we aim to discuss the utility of cardiac screening using novel modalities of imaging technology in the pre-HSCT phase.
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