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Published on: November 9, 2016
Emerging and re-emerging rickettsial infections
1Department of Pathology, New York Medical College School of Medicine, 30 Sunshine Cottage Road, Basic Sciences Building, Room 413, Valhalla, NY 10595, United States.
Abstract:
Rickettsial organisms are a diverse group of obligate intracellular bacteria; all species known to cause human disease are dependent on an arthropod vector and many are considered zoonotic diseases. Typical vectors of rickettsia are fleas, ticks, mites or lice. Humans become infected either when bitten or upon contact of broken skin or mucous membranes by infected secretions from an arthropod vector. The emergence and re-emergence of rickettsial diseases is a serious public health concern in the United States and abroad. Herein, the clinical and pathologic features of rickettsial diseases are described in tandem with the current scientific underpinnings. The histopathology of emerging and re-emerging rickettsiosis with species-specific discussion relating to vector issues and control are explored. Concepts of endemicity are addressed in the context of climate change and its impact on vector and sylvatic reservoirs, underscoring the need for clinical vigilance and broad consideration for encounters with these potentially life threating human pathogens.
Insights
Rickettsial diseases, caused by bacteria transmitted by arthropod vectors like ticks and fleas, are a growing public health concern. This review details their clinical features, pathology, and control, emphasizing vigilance against these zoonotic threats.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Rickettsial organisms are obligate intracellular bacteria transmitted by arthropod vectors (fleas, ticks, mites, lice).
- Many rickettsial diseases are zoonotic, posing significant public health risks globally.
- Human infection occurs through arthropod bites or contact with infected secretions.
Purpose of the Study:
- To describe the clinical and pathological features of rickettsial diseases.
- To review current scientific understanding of rickettsiosis.
- To explore histopathology, vector control, and the impact of climate change on disease emergence.
Main Methods:
- Review of clinical and pathological data.
- Analysis of scientific literature on rickettsial diseases.
- Discussion of histopathology, vector ecology, and epidemiology.
Main Results:
- Rickettsial diseases present diverse clinical and pathological manifestations.
- Emerging and re-emerging rickettsiosis require specific diagnostic and control strategies.
- Climate change influences vector distribution and disease endemicity.
Conclusions:
- Clinical vigilance and broad consideration for rickettsial infections are crucial.
- Understanding vector-borne disease dynamics is essential for public health preparedness.
- Integrated approaches to vector control and surveillance are needed to mitigate rickettsial disease threats.
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