[Application of mechanosensitive channels in sonogenetics]
Feifan Hong1, Yuezhou Li1,2
11. Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.
Summary
Sonogenetics uses ultrasound to control neuron activity via mechanosensitive channels (MSCs). This review covers progress in applying MSCs like TRP, K2P, and Piezo channels for non-invasive neuromodulation.
Area of Science:
- Neuroscience
- Biophysics
- Biotechnology
Background:
- Sonogenetics offers a non-invasive method for controlling neuronal activity.
- Mechanosensitive channels (MSCs) are key to sonogenetics due to their sensitivity to ultrasound.
- Targeted neuronal activation via ultrasound-sensitive channels is an emerging field.
Purpose of the Study:
- To review the current state of sonogenetics.
- To introduce various mechanosensitive channels (MSCs) applicable in sonogenetics.
- To highlight recent advancements in the application of MSCs for neuromodulation.
Main Methods:
- Review of literature on sonogenetics and mechanosensitive channels.
- Introduction of specific MSC families: Transient Receptor Potential (TRP) channels, two-pore-domain potassium (K2P) channels, and Piezo channels.
- Discussion of the principles of ultrasound-mediated activation of MSCs.
Main Results:
- Mechanosensitive channels (MSCs) are viable targets for sonogenetic neuromodulation.
- Different MSCs (TRP, K2P, Piezo) exhibit varying properties suitable for sonogenetics.
- Recent progress demonstrates the potential of sonogenetics for precise neural control.
Conclusions:
- Sonogenetics, utilizing mechanosensitive channels (MSCs), presents a promising non-invasive neuromodulation strategy.
- Further research into MSCs will refine sonogenetic techniques for therapeutic applications.
- The development of ultrasound-activated MSCs is advancing the field of targeted neural control.
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