Diffuse white matter alteration in CLIPPERS: Advanced MRI findings from two cases

Mauro Morassi1, Milena Cobelli1, Elena Ghiselli1

  • 1Department of Radiology, Neuroradiology and Angiology Unit, Fondazione Poliambulanza Istituto Ospedaliero, Via L. Bissolati 57, 25124 Brescia, Italy.

Summary

Advanced MRI revealed widespread white matter changes in patients with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). These findings suggest MRI can help identify CLIPPERS cases potentially progressing to lymphoma.

Related Concept Videos

Clipper Circuit01:18

Clipper Circuit

A clipper circuit is a fundamental wave-shaping device that harnesses the unique properties of diodes to alter and control waveform characteristics. This technology is widely used in electronic devices, especially in television and radar communication systems, where it enhances waveform modulation in both transmitters and receivers.
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...
865
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
217.1K
Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

The characteristics that enable us to distinguish one substance from another are called properties.
165.8K
Classifying Matter by State02:49

Classifying Matter by State

Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars. 
102.8K
The Atomic Theory of Matter02:59

The Atomic Theory of Matter

The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
127.2K
Classifying Matter by Composition03:35

Classifying Matter by Composition

Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.0K