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Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
Published on: August 16, 2019
Hyperdominant left anterior descending artery presenting as anterior wall ST segment elevation myocardial infarction:
Shahrukh Hashmani1, Abid Hussain Laghari1
1Aga Khan University Hospital, Karachi.
Insights
A rare coronary artery anomaly, where the left anterior descending artery continues as the posterior descending artery, was identified in a patient with acute myocardial infarction. Successful percutaneous coronary intervention restored blood flow.
Area of Science:
- Cardiology
- Anatomical Variations
- Interventional Cardiology
Background:
- Coronary artery anomalies are uncommon and can present with diverse clinical manifestations.
- Anatomical variations in coronary artery origins and distributions can impact myocardial perfusion and diagnostic interpretation.
- Understanding these variations is crucial for accurate diagnosis and effective treatment of ischemic heart disease.
Observation:
- A 75-year-old male presented with acute chest pain and ECG findings indicative of myocardial infarction.
- Cardiac catheterization revealed a 99% occlusion in the proximal left anterior descending (LAD) artery.
- A unique anatomical finding was the LAD artery wrapping around the apex to supply the territory typically supplied by the posterior descending artery (PDA).
Findings:
- The patient underwent successful primary percutaneous coronary intervention with a drug-eluting stent to the occluded LAD artery.
- The coronary angiogram demonstrated an anomalous LAD artery coursing over the apex and continuing as the PDA.
- A normally arising but small right coronary artery was also noted, highlighting a rare coronary anatomy.
Implications:
- This case underscores the importance of recognizing rare coronary artery anomalies during percutaneous coronary intervention.
- Accurate identification of anomalous coronary anatomy can prevent procedural complications and optimize treatment strategies.
- Further case reports on such variations can enhance the collective understanding and management of complex coronary artery disease.
Abstract:
We report on a 75 year-old man who presented with severe chest pain for four hours. Physical examination was unremarkable and he was haemodynamically stable. ECG done in the ED showed ST segment elevations along with Q waves in the anterior and inferior leads with T wave inversions. He was rushed to the catheterization lab where the left anterior descending (LAD) artery was 99%occluded in the proximal segment while distal left circumflex showed 50-60% lesion. He underwent primary percutaneous coronary intervention to LAD with drug eluting stent and made an uneventful recovery. The LADwas found to be wrapping around the apex and continuing as the posterior descending artery (PDA). To the best of our knowledge, there are few case reports on the continuation of LAD across the left ventricular apex as PDA in the presence of a normally arising but small right coronary artery.
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