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Changes in Body Weight Before and After Kidney Donation.
Ann Bugeja1,2, Sophie Harris2, Jaclyn Ernst2,3
1Division of Nephrology, Department of Medicine, The Ottawa Hospital, ON, Canada.
Canadian Journal of Kidney Health and Disease
|May 21, 2019
Summary
Living kidney donors with normal BMI lost weight before donation and maintained it post-donation. Overweight or obese donors gained weight after donation, highlighting the need for weight management to reduce end-stage kidney disease (ESKD) risk.
Area of Science:
- Nephrology
- Transplant Surgery
- Public Health
Background:
- Living kidney donation carries a low risk of end-stage kidney disease (ESKD).
- Obese and overweight living kidney donors face an elevated risk of ESKD.
- Clinical guidelines recommend weight loss for overweight/obese individuals before donation and weight maintenance post-donation.
Purpose of the Study:
- To examine weight change trajectories in living kidney donors before and after donation.
- To compare weight changes between normal BMI and overweight/obese donors.
Main Methods:
- Retrospective cohort study of 151 living kidney donors.
- Data collected included donation dates, recipient details, donor demographics, glycemic control markers, and weights at clinic visits.
- Paired Student's t-tests analyzed weight differences pre-donation and post-donation.
Main Results:
- Normal BMI donors lost weight pre-donation (mean difference 1.1 kg, P < .01) and maintained it post-donation.
- Overweight/obese donors showed no significant pre-donation weight change but gained weight post-donation (mean difference 2.3 kg, P < .0001).
- Median follow-up was 392 days.
Conclusions:
- Normal BMI donors successfully maintained a healthy weight post-donation.
- Overweight/obese donors experienced significant weight gain one year after donation.
- Enhanced weight management strategies are crucial for obese and overweight kidney donors to mitigate ESKD risk.
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