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Related Experiment Video

Updated: Jan 24, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

Zinc-dysprosium functionalized amyloid fibrils.

Stavroula I Sampani¹, Youssra K Al-Hilaly, Sharali Malik

¹School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK. L.c.serpell@sussex.ac.uk G.Kostakis@sussex.ac.uk.

Dalton Transactions (Cambridge, England : 2003)

|May 21, 2019

Summary

A novel heterometallic zinc-dysprosium (Zn2Dy2) assembly decorates amyloid fibrils, creating a functional material with catalytic Lewis acid properties for advanced applications.

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Area of Science:

Materials Science
Catalysis
Biomaterials

Background:

Amyloid fibrils are protein aggregates with ordered structures.
Metal complexes can impart novel functionalities to biomaterials.
Developing hybrid materials with catalytic activity is an active research area.

Purpose of the Study:

To covalently attach a heterometallic Zn2Dy2 entity to an amyloid fibril core.
To investigate the catalytic properties of the functionalized amyloid assembly.
To explore the potential of amyloid fibrils as scaffolds for catalytic metal centers.

Main Methods:

Synthesis of a heterometallic Zn2Dy2 complex.
Covalent functionalization of amyloid fibrils with the Zn2Dy2 entity.
Characterization of the resulting hybrid material.
Evaluation of catalytic activity in a model Lewis acid reaction.

Main Results:

Successful decoration of amyloid fibrils with Zn2Dy2 entities was achieved.
The functionalized assembly demonstrated significant catalytic Lewis acid behavior.
Partially saturated metal centers within the Zn2Dy2 entity are crucial for activity.

Conclusions:

Amyloid fibrils can serve as effective scaffolds for catalytic metal complexes.
The Zn2Dy2-amyloid hybrid material exhibits promising catalytic Lewis acid properties.
This work opens avenues for designing bio-inspired catalysts and functional nanomaterials.