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Related Concept Videos

The Synapse02:47

The Synapse

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Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
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Postsynaptic Potential (PSP)01:32

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Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
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Plasticizers01:31

Plasticizers

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Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
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Plasticity00:58

Plasticity

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Plastic Behavior01:21

Plastic Behavior

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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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Plastic Deformations01:14

Plastic Deformations

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It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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Related Experiment Video

Updated: Jan 24, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
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Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

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Postsynaptic plasticity of GABAergic synapses.

Andrea Barberis1

  • 1Plasticity of Inhibitory Networks, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, Genova, Italy.

Neuropharmacology
|May 21, 2019
PubMed
Summary

Inhibitory synapses, like excitatory ones, exhibit plasticity. This review details molecular mechanisms of postsynaptic GABAergic plasticity, focusing on GABAA receptor trafficking and gephyrin interactions.

Keywords:
GABAA receptorsGABAergic synapseGephyrinGlutamatergic plasticityLateral diffusionSynaptic plasticity

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Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
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Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

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Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse
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Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
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Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Neuronal network flexibility is primarily attributed to excitatory synapse plasticity.
  • Inhibitory synapses also exhibit various forms of synaptic plasticity.
  • Understanding inhibitory synapse plasticity is crucial for comprehending neural network function.

Purpose of the Study:

  • To review recent advances in the molecular mechanisms of postsynaptic GABAergic plasticity.
  • To highlight the role of GABAA receptor modulation at postsynaptic sites.
  • To discuss the importance of interactions between GABAA receptors and scaffold proteins like gephyrin.

Main Methods:

  • Literature review of recent research on synaptic plasticity.
  • Focus on molecular mechanisms governing postsynaptic GABAergic function.
  • Analysis of studies investigating protein-protein interactions at inhibitory synapses.

Main Results:

  • Postsynaptic GABAergic plasticity involves the modulation of GABAA receptor numbers.
  • Gephyrin and other scaffold proteins are critical for GABAergic synapse organization and function.
  • Recent insights reveal the dynamics of GABAA receptor lateral diffusion and gephyrin organization.

Conclusions:

  • GABAergic synaptic plasticity is a key contributor to neuronal network flexibility.
  • The trafficking and interactions of GABAA receptors with gephyrin are central to inhibitory plasticity.
  • Further research into these molecular dynamics will advance our understanding of brain function.