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Alcoholic-like drinking in simian social groups.

T J Crowley, A E Andrews

    Psychopharmacology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed two protocols to induce sustained, high-dose alcohol drinking in Macaca nemestrina monkeys, mimicking early human alcoholism biomedical changes. These methods allow studying social and genetic influences on alcohol consumption behaviors.

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    Area of Science:

    • Primate research
    • Neuroscience
    • Addiction studies

    Background:

    • Understanding the complex factors contributing to alcohol use disorders is crucial.
    • Developing reliable animal models for studying alcohol consumption is essential for research.

    Purpose of the Study:

    • To establish two novel protocols for inducing sustained, high-dose, alcohol-reinforced oral drinking in Macaca nemestrina.
    • To investigate the effects of food deprivation and flavor on alcohol consumption.
    • To examine potential social and genetic influences on alcohol drinking behaviors.

    Main Methods:

    • Two protocols were employed: one with unflavored alcohol and food deprivation, the other with flavored alcohol and no food deprivation.
    • Alcohol and food were initially presented in a 2-hour daily session, followed by a return to continuous food availability.

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  • Biomedical changes and blood alcohol concentrations were monitored.

    • Main Results:

    • Both protocols successfully induced daily high-dose alcohol drinking, leading to biomedical changes resembling early human alcoholism.
    • Some animals sustained high blood alcohol concentrations (>100 mg/dl) even after returning to baseline feeding conditions, potentially linked to social rank.
    • Alcohol reinforced the drinking of flavored solutions, and initial food deprivation led to heavier drinking, though protocols became equivalent later.

    Conclusions:

    • The developed protocols provide a valuable tool for studying sustained, high-dose alcohol consumption in a primate model.
    • These methods facilitate the examination of combined social and genetic influences on alcohol-like drinking behaviors.
    • The findings suggest that social hierarchy may play a role in maintaining high alcohol consumption.