An Optical Exposé of Cortical Function
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Updated: Jan 24, 2026

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
Published on: November 19, 2012
Naomi Shvedov1, David J Margolis1
1Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Abstract:
Neural imaging benefits from optical access to widespread brain areas. A recent study (Ghanbari et al. Nat. Commun. 2019;10;1500) introduces See-Shell, a transparent polymer skull that reveals the entire dorsal cortex in mice. See-Shells are 3D-printed, customizable, and modifiable for combined neural recording and manipulation, offering advantages for high-resolution, multiscale measures of in vivo brain function.
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