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Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
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An Optical Exposé of Cortical Function.

Naomi Shvedov1, David J Margolis1

  • 1Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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|May 22, 2019
PubMed
Summary

Researchers developed See-Shell, a transparent 3D-printed skull for mice. This innovation allows clear optical access to the entire dorsal cortex, enhancing in vivo brain function studies.

Keywords:
brain functionimagingmicroscopyneural circuitsplasticitysee-shell

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Optical access to widespread brain areas is crucial for neural imaging.
  • Existing methods for in vivo brain observation are often limited in scope or invasiveness.

Purpose of the Study:

  • To introduce a novel transparent skull implant, See-Shell, for enhanced visualization of the mouse brain.
  • To demonstrate the utility of See-Shell for high-resolution, multiscale in vivo neural recording and manipulation.

Main Methods:

  • Development of a customizable, 3D-printed transparent polymer skull (See-Shell).
  • Surgical implantation of See-Shell in mice to enable visualization of the dorsal cortex.
  • Integration of neural recording and manipulation tools with the See-Shell implant.

Main Results:

  • See-Shell provides clear optical access to the entire dorsal cortex in mice.
  • The transparent skull is customizable and amenable to modifications for combined neural recording and manipulation.
  • Demonstrated potential for high-resolution, multiscale in vivo brain function measurements.

Conclusions:

  • See-Shell represents a significant advancement for optical neuroimaging in mice.
  • The implant facilitates comprehensive in vivo studies of brain function.
  • Customizable and versatile, See-Shell offers broad applicability in neuroscience research.