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Updated: Jan 24, 2026

Gastrointestinal Motility Monitor GIMM
Published on: December 1, 2010
Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization
April H Nguyen1, William R Miller2, Cesar A Arias3
1Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center, McGovern School of Medicine, Houston, TX, USA; Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, McGovern School of Medicine, Houston, TX, USA.
Abstract:
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695-705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.
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