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Driving complex flow waveforms with a linear voice coil actuator.

Dylan C Young1, Jacob M Brehm1, Jan Scrimgeour1

  • 1Department of Physics, Clarkson University, Potsdam, New York 13699, USA.

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Researchers developed a precise method to control fluid flow in microfluidic devices. This technique allows for the generation of complex, on-demand oscillations and pulsatile flows, mimicking biological systems.

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Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Microfluidics

Background:

  • Microfluidic applications require precise control over fluid flow dynamics.
  • Generating controlled oscillatory and pulsatile flows is crucial for simulating physiological conditions.
  • Existing methods may lack the flexibility or cost-effectiveness for complex waveform generation.

Purpose of the Study:

  • To develop a low-cost system for generating controllable oscillatory and pulsatile fluid flows in microfluidics.
  • To overcome frequency-dependent limitations in fluidic systems driven by deformable chambers.
  • To enable the generation of arbitrary complex waveforms for microfluidic applications.

Main Methods:

  • Utilized a deformable chamber actuated by a linear voice coil actuator to generate fluid flow.
  • Implemented precise system calibration to counteract frequency-dependent input-output relationships.
  • Optimized a multistage exponential smoothing model using calibration data.
  • Combined modulated flow with a constant background flow from a syringe pump.

Main Results:

  • Achieved on-demand generation of sinusoidal fluid flow oscillations with controlled amplitudes (0.1–1+ ml/min) across a wide frequency range (0.1–10 Hz).
  • Successfully overcame system frequency dependence through precise calibration.
  • Demonstrated the generation of arbitrary complex waveforms, including pulsatile flows mimicking the human vascular system.
  • Developed a cost-effective and flexible fluid flow control system.

Conclusions:

  • The developed system offers precise and flexible control over microfluidic flow rates.
  • The calibration and modeling approach effectively addresses inherent system frequency dependencies.
  • This technology enables realistic simulation of physiological pulsatile flows in microfluidic devices.
  • The low-cost actuator and system design make it suitable for various microfluidic applications.