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Related Experiment Videos

Single dose bromocriptine microcapsules in postpartum lactation inhibition.

L Svanberg, I Lancranjan, T Arvidsson

    Acta Obstetricia Et Gynecologica Scandinavica
    |January 1, 1987
    PubMed
    Summary

    Parlodel LA (Pravidel 50 mg) effectively prevented postpartum lactation in 10 women. This single injection demonstrated high efficacy and safety, with no rebound lactation observed during the 28-day study.

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    Area of Science:

    • Obstetrics and Gynecology
    • Endocrinology
    • Pharmacology

    Background:

    • Postpartum lactation can cause discomfort and complications.
    • Effective pharmacological interventions are sought for lactation suppression.

    Purpose of the Study:

    • To evaluate the clinical efficacy and safety of Parlodel LA (Pravidel 50 mg) for preventing postpartum lactation.
    • To assess prolactin level changes and occurrence of rebound lactation.

    Main Methods:

    • A single intramuscular injection of Parlodel LA (Pravidel 50 mg) was administered to 10 postpartum women.
    • Efficacy was assessed over a 28-day observation period.
    • Prolactin plasma levels and menstrual bleeding were monitored.

    Main Results:

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    • Overall efficacy was rated as very good in 8 women and good in 2 women.
    • No instances of rebound lactation were reported.
    • Prolactin plasma levels normalized within 4 days in 9 women.
    • Menstrual bleeding resumed in 9 women between 4 to 6 weeks post-treatment.

    Conclusions:

    • Pravidel 50 mg is an effective and safe option for suppressing postpartum lactation.
    • The treatment leads to rapid normalization of prolactin levels.
    • The study supports the use of Pravidel for postpartum lactation management.