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Lipoprotein particles in patients with pediatric Cushing disease and possible cardiovascular risks

Angeliki Makri1, Anita Cheung2, Ninet Sinaii3

  • 1Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA. angeliki.makri@gmail.com.

Pediatric Research
|May 22, 2019
PubMed

Insights

Nuclear magnetic resonance (NMR) spectroscopy reveals improved lipid profiles in pediatric Cushing disease (CD) patients after remission. This novel approach aids in assessing cardiovascular risk in children with CD.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Risk Assessment
  • Metabolic Disorders

Background:

  • Cardiovascular complications are a major cause of mortality in adults with Cushing disease (CD).
  • Cardiovascular risk factors in pediatric CD patients are not well understood.
  • Nuclear magnetic resonance (NMR) spectroscopy offers a novel method for measuring lipoprotein particles to assess cardiovascular risk.

Purpose of the Study:

  • To analyze the NMR lipid profile in pediatric CD patients.
  • To compare lipid profiles before and 1 year after remission in pediatric CD patients.
  • To evaluate the utility of NMR spectroscopy in assessing cardiovascular risk in pediatric CD.

Main Methods:

  • Utilized the Vantera NMR analyzer to obtain NMR lipid profiles.
  • Analyzed frozen serum samples from 33 pediatric CD patients (mean age 13.8 years).
  • Data collected from patients evaluated between 1997 and 2017 at the NIH Clinical Center.

Main Results:

  • Significant changes in GlycA, triglyceride-rich lipoprotein (TRLP) particles, low-density lipoprotein (LDL) particles, high-density lipoprotein (HDL) particles, total cholesterol, LDL-cholesterol, HDL-cholesterol, GlycA inflammatory biomarker, and apolipoprotein B and A1 (ApoA1) concentrations were observed post-remission (p < 0.05).
  • Most lipid variables improved after CD remission.
  • HDL and ApoA1 levels did not show significant improvement post-remission.

Conclusions:

  • NMR lipoprotein profiling is a potentially valuable tool for assessing cardiovascular risk in pediatric CD patients.
  • Lipid profiles generally improve following remission of CD in pediatric patients.
  • Further research may be needed to understand the persistent changes in HDL and ApoA1.
Abstract

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