Related Experiment Video
Updated: Jan 24, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
A Randomized Controlled Trial Comparing Two Lung Expansion Therapies After Upper Abdominal Surgery.
Daniel D Rowley1, Thomas P Malinowski2, Joseph L Di Peppe2
1Pulmonary Diagnostics and Respiratory Therapy Services, University of Virginia Medical Center, Charlottesville, Virginia. ddr8a@virginia.edu.
Incentive spirometry (IS) and EzPAP lung expansion therapy show similar effectiveness in improving ventilation and reducing complications after upper abdominal surgery. Both methods are comparable for patients not on mechanical ventilation.
Area of Science:
- Pulmonary Medicine
- Critical Care
- Surgical Outcomes
Background:
- Lung expansion therapy is crucial for improving alveolar ventilation and preventing postoperative pulmonary complications.
- The comparative effects of different lung expansion therapies on non-intubated patients remain under-described.
- Upper abdominal surgery poses a significant risk for pulmonary complications.
Purpose of the Study:
- To compare the effectiveness of incentive spirometry (IS) versus EzPAP lung expansion therapy in altering postoperative ventilation distribution.
- To assess the incidence of postoperative pulmonary complications between IS and EzPAP groups.
- To determine if EzPAP offers an advantage over IS in dorsal ventilation redistribution.
Main Methods:
- A randomized controlled trial involving 112 adult patients undergoing upper abdominal surgery.
- Patients received either IS or EzPAP therapy three times daily from postoperative days 1-5.
- Electrical impedance tomography (EIT) was used to measure dorsal end-expiratory lung impedance changes (ΔEELI%) on postoperative days 1, 3, and 5.
Main Results:
- No significant difference in the increase of dorsal ΔEELI% was observed between the IS and EzPAP groups on postoperative days 1, 3, or 5.
- Both therapies led to an increase in dorsal ventilation redistribution post-therapy.
- Hospital length of stay and the incidence of postoperative pulmonary complications were similar between the two groups.
Conclusions:
- Neither incentive spirometry nor EzPAP therapy demonstrated a significant advantage in improving dorsal lung ventilation or reducing postoperative pulmonary complications in this patient cohort.
- The study found no significant difference in outcomes between IS and EzPAP for non-intubated patients after upper abdominal surgery.
- Both lung expansion therapies are viable options for postoperative care in this setting.
More Related Videos
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Trial and Error and Algorithm
Random Error
Random Variables
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
Randomized Experiments
Simple randomization
Simple...

