Related Experiment Video

Updated: Jan 24, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

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Emerging roles of microRNAs in morphine tolerance

Jiangju Huang1, Jian Wang1, Qulian Guo1

  • 1Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.

Journal of Pain Research
|May 23, 2019
PubMed

Insights

Morphine tolerance, a challenge in pain management, involves microRNAs (miRNAs). These small RNAs regulate gene expression and are implicated in the reduced effectiveness of morphine for pain relief.

Area of Science:

  • Biochemistry
  • Genetics
  • Pharmacology

Background:

  • Morphine is a key analgesic for moderate-to-severe pain.
  • Prolonged morphine use induces tolerance, limiting its efficacy.
  • Mechanisms of morphine tolerance are not fully elucidated.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in morphine tolerance.
  • To explore how miRNAs affect the antinociceptive effects of opioids.

Main Methods:

  • Literature review of studies investigating miRNAs and opioid tolerance.
  • Analysis of miRNA involvement in post-transcriptional gene regulation.

Main Results:

  • Morphine administration alters the expression of specific miRNAs.
  • miRNAs contribute to the development of tolerance to morphine's pain-relieving effects.

Conclusions:

  • MicroRNAs are significant regulators in morphine tolerance.
  • Targeting miRNAs may offer novel strategies for managing opioid tolerance and pain.
Keywords:
CaMKII/NMDARMORmicroRNAmorphine toleranceβ-arrestin 2

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