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Microfluidic-controlled optical router for lab on a chip.

Jiri Dietvorst1, Jeroen Goyvaerts, Tobias Nils Ackermann

  • 1Institut de Microelectrònica de Barcelona (IMB-CNM, CSIC), Campus UAB, 08193 Bellaterra, Barcelona, Spain. xavier.munoz@imb-cnm.csic.es.

Lab on a Chip
|May 23, 2019
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Summary
This summary is machine-generated.

This study introduces a microfluidic optical router for lab on a chip (LoC) devices, enabling multiplexed analysis with a single light source and detector. This innovation simplifies optical detection in LoCs for potential point-of-care applications.

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Area of Science:

  • Optofluidics
  • Microfluidics
  • Photonics
  • Lab on a Chip (LoC) technology

Background:

  • Multiplexed analysis on lab on a chip (LoC) devices offers reduced sample and reagent volumes.
  • Optical detection in multiplexed LoCs is sensitive but technologically complex due to multiple light sources and detectors.
  • Existing multiplexed optical LoCs face challenges in integrating numerous optical components.

Purpose of the Study:

  • To develop a microfluidic-controlled optical router for multiplexed optical measurements in LoCs.
  • To enable measurements in four optical channels using a single light source and detector.
  • To overcome the technological complexity of integrating multiple optical components in LoCs.

Main Methods:

  • Fabrication of an optofluidic device using soft-lithography in polydimethylsiloxane (PDMS).
  • Utilizing a microfluidic-controlled optical router with sequentially connected micro-chambers.
  • Employing total internal reflection (TIR) at PDMS-air interfaces to redirect light based on chamber liquid content.

Main Results:

  • Demonstrated a microfluidic optical router enabling four-channel measurements with a single light source and detector.
  • Achieved high performance with low cross-talk (<2%) and high switching frequencies (0.343 ± 0.006 Hz).
  • Reported a stable signal for up to 91% of the switching time, indicating robust operation.

Conclusions:

  • The developed optofluidic router is miniaturized, low-cost, simple, and robust.
  • This technology facilitates monolithic integration into LoCs using standard microfabrication.
  • The device is suitable for next-generation multiplexed photonic LoCs for biomarker analysis, including point-of-care applications.