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Related Concept Videos

Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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External Anatomy of the Kidney01:21

External Anatomy of the Kidney

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The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

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The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Related Experiment Video

Updated: Oct 8, 2025

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids
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Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids

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[Kidney organoids].

Clara Steichen1, Sébastien Giraud2, Thierry Hauet3

  • 1Inserm U1082 - IRTOMIT (Ischémie reperfusion en transplantation d'organes mécanismes et innovations thérapeutiques), Poitiers, F-86000, France - Université de Poitiers, Faculté de médecine et de pharmacie, Poitiers, F-86000, France.

Medecine Sciences : M/S
|May 23, 2019
PubMed
Summary
This summary is machine-generated.

Kidney organoids derived from pluripotent stem cells offer a promising alternative to traditional models. These complex mini-organs aid in disease modeling, drug screening, and advancing regenerative medicine for kidney repair.

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Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

Published on: April 13, 2021

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Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Developmental biology

Background:

  • Traditional in vitro and in vivo models have limitations for studying kidney development and disease.
  • Understanding embryonic kidney development is crucial for creating functional kidney organoids.
  • Pluripotent stem cells provide a versatile source for generating complex, organized kidney structures.

Purpose of the Study:

  • To review the development and applications of kidney organoids derived from pluripotent stem cells.
  • To highlight kidney organoids as a viable alternative to existing research models.
  • To discuss the potential of kidney organoids in disease modeling, drug discovery, and regenerative medicine.

Main Methods:

  • Differentiation of pluripotent stem cells into kidney organoids.
  • Utilizing knowledge of embryonic kidney development to establish differentiation protocols.
  • Genome editing and patient-derived induced pluripotent stem cells (iPSCs) for disease modeling.

Main Results:

  • Development of complex, organized kidney organoids with diverse renal cell types.
  • Successful recapitulation of kidney physiopathological mechanisms, such as cyst formation in polycystic kidney disease.
  • Demonstration of kidney organoids' utility in high-throughput screening for nephrotoxic and therapeutic compounds.

Conclusions:

  • Kidney organoids represent a significant advancement over traditional research models.
  • These organoids hold substantial promise for modeling kidney diseases and accelerating drug development.
  • Further technological advancements are needed to overcome barriers for kidney organoid application in tissue repair.