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Updated: Jan 24, 2026

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

7.5K

The current state of molecular testing in the treatment of patients with solid tumors, 2019

Wafik S El-Deiry1, Richard M Goldberg2, Heinz-Josef Lenz3

  • 1Associate Dean for Oncologic Sciences, Warren Alpert Medical School; Director, Joint Program in Cancer Biology, Brown University and the Lifespan Cancer Institute; Professor of Pathology & Laboratory Medicine and Professor of Medical Science, Brown University, Providence, RI.

CA: a Cancer Journal for Clinicians
|May 23, 2019
PubMed

Insights

Molecular profiling is now essential for metastatic solid tumors, with new treatments approved based on genetic testing, not tumor location. This review covers current standards and future directions in precision medicine.

Area of Science:

  • Oncology
  • Genetics
  • Clinical Practice

Background:

  • Molecular profiling has rapidly evolved, becoming crucial for treating metastatic solid tumors.
  • New cancer therapies are increasingly approved based on molecular testing results, shifting focus from tumor site.
  • Outdated molecular profiling tests may yield inaccurate results, necessitating updated approaches.

Purpose of the Study:

  • To provide an up-to-date overview of molecular profiling and precision medicine.
  • To discuss current practice standards in molecular testing for cancer patients.
  • To offer insights into the future of molecular profiling in clinical oncology.

Main Methods:

  • Review of current literature and clinical practice guidelines.
  • Analysis of recent advancements in molecular profiling technologies.
  • Synthesis of information on newly approved molecularly targeted therapies.

Main Results:

  • Broad molecular profiling is now a near-essential component of care for metastatic solid tumors.
  • Treatment decisions and drug approvals are increasingly driven by molecular alterations rather than tumor histology.
  • Significant advancements in molecular profiling technologies require continuous updates to clinical practice.

Conclusions:

  • Molecular profiling is a cornerstone of modern precision medicine in oncology.
  • Healthcare providers must stay informed about evolving molecular profiling techniques and standards.
  • The future of cancer treatment lies in personalized approaches guided by comprehensive molecular data.
Keywords:
biomarkerscancerdrug targetgene expression profilingmolecular profilingmolecular-targeted therapymutationprecision medicinesequence analysis

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