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Related Concept Videos

What is Homeostasis?01:16

What is Homeostasis?

53.1K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
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pH Homeostasis01:31

pH Homeostasis

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Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.9K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.9K
C4 Pathway and CAM01:27

C4 Pathway and CAM

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
48.9K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.0K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.0K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.2K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.2K

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Related Experiment Video

Updated: Jan 24, 2026

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

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The Timed Pathway to Homeostasis.

Natalia Torow1, Mathias W Hornef1

  • 1Institute of Medical Microbiology, University Clinic RWTH Aachen, Aachen, Germany.

Immunity
|May 23, 2019
PubMed
Summary

A specific immune response during early infancy, known as the weaning reaction, primes the gut microbiome to prevent adult immune diseases. This process involves diet, microbes, and development for immune balance.

Area of Science:

  • Immunology
  • Microbiology
  • Developmental Biology

Background:

  • The early life gut microbiome plays a critical role in immune system development.
  • Immune homeostasis is essential for preventing chronic inflammatory and autoimmune diseases.

Purpose of the Study:

  • To describe the "weaning reaction," a critical immune event in early infancy.
  • To elucidate the role of microbiota-induced innate immune stimulation in establishing long-term immune protection.

Main Methods:

  • Observational study detailing immune responses during the third and fourth weeks post-birth.
  • Analysis of the interplay between dietary factors, microbial colonization, and infant development.

Main Results:

  • Identified a transient, microbiota-induced innate immune stimulation occurring specifically between weeks 3 and 4 postpartum.

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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
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  • Demonstrated that this precisely timed "weaning reaction" is linked to protection against immune-mediated enteric diseases later in life.

    • Conclusions:

    • The "weaning reaction" is a crucial, non-redundant developmental process.
    • Coordinated dietary, microbial, and developmental signals are vital for establishing immune homeostasis and preventing adult enteric diseases.