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Association between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly

Erdoğan Sökmen1, Cahit Uçar2, Serkan Sivri3

  • 1Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey, erdoganmen@gmail.com.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|May 23, 2019
PubMed

Insights

Non-dipper hypertension, a higher-risk condition, shows elevated levels of Growth Differentiation Factor 15 (GDF-15). This study suggests GDF-15 may help predict non-dipper hypertension in newly diagnosed patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Non-dipper hypertension presents a greater cardiovascular risk than dipper hypertension.
  • Growth Differentiation Factor 15 (GDF-15) is an emerging biomarker for cardiovascular disease.
  • Left ventricular hypertrophy was excluded in newly diagnosed hypertension patients.

Purpose of the Study:

  • To investigate the association between circadian blood pressure patterns and serum GDF-15 levels.
  • To evaluate GDF-15 as a potential predictor of non-dipper hypertension.
  • To analyze GDF-15 levels in relation to cardiovascular risk markers.

Main Methods:

  • 24-hour ambulatory blood pressure monitoring (ABPM) was used to classify patients.
  • Newly diagnosed hypertensive patients were categorized into non-dipper (n=66) and dipper (n=60) groups.
  • Serum GDF-15 levels were quantified using ELISA, alongside other clinical and echocardiographic parameters.

Main Results:

  • Serum GDF-15 levels were significantly higher in non-dipper hypertensive patients compared to dippers and controls (p < 0.001).
  • GDF-15 positively correlated with total cholesterol, nighttime systolic and diastolic BP, and negatively with E' velocities.
  • GDF-15 and nighttime diastolic BP were independently associated with the non-dipper hypertension pattern.

Conclusions:

  • Growth Differentiation Factor 15 (GDF-15) is upregulated in non-dipper hypertension.
  • GDF-15, along with nighttime diastolic BP, independently predicts the non-dipping pattern.
  • GDF-15 may serve as a valuable predictive marker for identifying non-dipper hypertension.
Abstract

Keywords:
Circadian patternDipping hypertensionGDF-15Non-dipper hypertension

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