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Updated: Jan 24, 2026

Preparation of DMMTAV and DMDTAV Using DMAV for Environmental Applications: Synthesis, Purification, and Confirmation
Published on: March 9, 2018
Scalable Synthesis of Diazeniumdiolates: Application to the Preparation of MK-8150
Yong-Li Zhong1, Mark Weisel1, Guy R Humphrey1
1Department of Process Research and Development, MRL , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
Abstract:
Synthetic diazeniumdiolate (DAZD)-based nitric oxide is utilized to modulate the nitric oxide (NO) concentration in cellular environments and to control physiological processes, yet chemists are still struggling to find efficient and scalable methodologies that will enable them to access sufficient quantities of the high-energy diazeniumdiolate intermediates for biological studies. Now, a general, scalable, safer, and high-yielding new methodology adaptable to the large-scale synthesis of DAZDs has been developed.
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