Related Experiment Video
Updated: Jan 24, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Antimicrobial Activity of Substituted Benzopentathiepin-6-amines
Tatyana M Khomenko1,2, Dina V Korchagina1, Dmitry S Baev1,2
1Novosibirsk Institute of Organic Chemistry, Lavrentjev av. 9, Novosibirsk, 630090, Russia.
Abstract:
A number of substituted benzopentathiepin-6-amines and their analogues without a polysulfur ring were synthesized and evaluated in vitro for antimicrobial activity against a panel of reference bacterial and fungal strains. Trifluoroacetamide 14 demonstrated high antibacterial activity against Staphylococcus aureus (MRSA strain) with a MIC of 4 μg/mL, which was four-fold higher than the activity of a reference drug amoxicillin. This compound was also most active against the Candida albicans fungus (MIC of 1 μg ml-1), whereas amide 17 containing a morpholine substituent was most active against the Cryptococcus neoformans fungus (MIC of 2 μg ml-1). These compounds have no hemolytic activity and are low cytotoxic. Replacement of the pentathiepine ring with 1,3-dithiolan-2-one or 1,3-dithiolane moieties leads to loss of antimicrobial activity. Based on the QSAR analysis and molecular docking data, bacterial DNA ligase might be one of the targets for the antibacterial activity of substituted benzopentathiepin-6-amines against S. aureus.
More Related Videos
Related Concept Videos
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Preparation of Amines: Alkylation of Ammonia and Amines
Each alkylation step makes the nitrogen center more nucleophilic, which triggers successive alkylations until a quaternary ammonium salt is formed. Considering...
Antimicrobial Effectiveness
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Structure of Amines
Amines: Introduction

