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Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse.
Artemis Gogos1, Michael J Federle2
1Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, United States.
Frontiers in Cellular and Infection Microbiology
|May 24, 2019
Summary
Streptococcus pyogenes (GAS) causes pharyngitis and colonizes the human throat. This review compares GAS pharyngeal colonization in humans and mice to assess the murine model
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Streptococcus pyogenes (GAS) is a human pathogen causing global pharyngitis and asymptomatic colonization.
- Understanding GAS-host interactions in the pharynx is crucial for differentiating infection from colonization.
Purpose of the Study:
- To review bacterial and host factors for GAS pharyngeal persistence in humans.
- To detail bacterial and host factors for GAS pharyngeal colonization in murine models.
- To compare human and murine models for GAS pharyngeal interaction.
Main Methods:
- Literature review of studies on GAS pharyngeal colonization.
- Analysis of bacterial factors influencing GAS persistence.
- Examination of host factors involved in GAS-pharyngeal interactions.
Main Results:
- Identified key bacterial virulence factors and host immune responses in human GAS colonization.
- Described specific bacterial and host elements facilitating GAS colonization in the murine pharynx.
- Highlighted similarities and differences between human and murine GAS pharyngeal colonization.
Conclusions:
- The murine model offers insights into GAS pharyngeal colonization but has limitations.
- Further research is needed to refine the murine model for human GAS-pharyngeal interaction studies.
Keywords:
carriagecolonization modelhost pathogen interactioninnate immune responsepharyngeal colonizationpharyngitisMore Related Videos
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