Related Experiment Video
Updated: Jan 24, 2026

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
Published on: October 15, 2016
Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes
Jun-Long Zhu1, Zheng Xu, Yangyang Yang
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai, P. R. China. lxu@chem.ecnu.edu.cn.
Abstract:
In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarizes the recent advances in the design and preparation of small-molecule fluorescent probes for specific detection of chemical species inside lysosomes. In addition, their properties and applications for the detection and imaging of pH, H2O2, HOCl, O2˙-, lipid peroxidation, H2S, HSO3-, thiols, NO, ONOO-, HNO, Zn2+, Cu2+, enzymes, etc. in lysosomes are discussed as well.
Related Concept Videos
Lysosomes
Lysosomal Hydrolases
Molecules and Compounds
What is a Species?
Keystone Species
Formation of Species

