Related Experiment Video
Updated: Jan 24, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
[Sphenopalatine ganglion block for treatment of post-dural puncture headache]
Mads Seit Jespersen1, Pia Therese Jæger, Karen Lehrmann Ægidius
1mads.seit.jespersen@regionh.dk.
Abstract:
In this review, we discuss transnasal sphenopalatine ganglion (SPG) block: a new, simple and minimally invasive procedure for the treatment of post-dural puncture headache (PDPH) by applying local anaesthesia through the patient's nose to the nasopharynx. PDPH is a severe and disabling complication sometimes caused by lumbar puncture or unintentional dural puncture. Current treatment includes epidural blood patch, which is an invasive and resource-demanding procedure with the potential of causing severe complications such as infection and paralysis. SPG block seems to be effective and may ease and improve the treatment of PDPH.
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