Novel topical dermal repair: A clinical analysis

There is an increasing interest in and demand for noninvasive anti-aging treatments, and cosmeceuticals are an effective adjunct treatment to in-office cosmetic treatments.

This study evaluates the short-term cosmetic benefits of a topical anti-wrinkle cream (Ultrascript Dermal Regenesis, Montclair, NJ) and a topical evening DNA repair serum (Dermal DNA Repair Serum with the active ingredient AC-11 from Optigenex INC).

Fourteen women of all Fitzpatrick skin types were randomized to receive either the topical anti-wrinkle cream (AM cream) only or the AM cream and the topical evening DNA repair serum (PM serum) for 16 weeks. Subjects noted their subjective improvement in wrinkles, pore size, hyperpigmentation, and overall skin quality. Two blinded physicians evaluated the appearance of wrinkles pre- and postapplication of the AM cream.

Participants who applied the AM cream only reported subjective improvement in wrinkles and overall quality of their skin. Immediate improvement of wrinkles was seen after the application of the AM cream. Subjects who applied both the AM cream and PM serum noted improvement in pore size.

This novel anti-wrinkle cream is a safe and effective topical treatment for the immediate, but short-term improvement of wrinkles. Prolonged use of the cream and continued follow-up may show additional long-term benefits.