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Structural Characterization of Reconstituted Bioactive-Loaded Nanodomains after Embedding in Films Using Electron
Eva Abramov1, Maria Francesca Ottaviani2, Alexander I Shames3
1The Ratner Chair of Chemistry, Casali Institute of Applied Chemistry, The Institute of Chemistry , The Hebrew University of Jerusalem , Edmond J. Safra Campus , Givat Ram, Jerusalem 91904 , Israel.
Langmuir : the ACS Journal of Surfaces and Colloids
|May 24, 2019
Summary
This study developed a novel drug delivery system using gellan gum films loaded with microemulsion nanodomains. These films enable controlled release of curcumin, enhancing its bioavailability through spontaneous nanodomain reformation.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Science
Background:
- Microemulsions (MEs) show promise for drug delivery but lack controlled release and bioavailability enhancement.
- Incorporating drug-loaded nanodomains into a natural polymeric film offers a stable reservoir for improved drug delivery.
Purpose of the Study:
- To develop and characterize a novel drug delivery system using gellan gum films loaded with microemulsion nanodomains.
- To investigate the stability and drug release profile of these nanodomain-loaded films.
- To confirm the integrity of microemulsion structures after film dissolution and reconstitution.
Main Methods:
- Preparation of gellan gum films loaded with empty and curcumin-loaded microemulsions.
- Characterization using electron paramagnetic resonance (EPR) and self-diffusion nuclear magnetic resonance (SD-NMR) techniques.
- Analysis of nanodomain microstructure and component diffusivity before and after film dissolution.
Main Results:
- Microemulsion nanodomains spontaneously and reversibly reformed after film dissolution.
- The gellan gum film did not perturb the embedded microemulsion nanodomain structure.
- Curcumin remained solubilized at the microemulsion droplet/water interface post-dissolution, indicating retained drug-loading capacity.
Conclusions:
- Gellan gum films loaded with microemulsion nanodomains represent a novel drug delivery vehicle.
- The system ensures the stability of nanodomains and facilitates controlled drug release.
- This approach offers potential for enhanced bioavailability of hydrophobic drugs like curcumin.
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