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In vitro activity of Ro 19-5247 (T-2525) and interpretive criteria for disk diffusion susceptibility testing.
Journal of Clinical Microbiology
|July 1, 1987
Summary
Ro 19-5247 demonstrates superior in vitro activity against Enterobacteriaceae compared to other oral antibiotics. Susceptibility testing criteria were established for Ro 19-5247 disks, aiding clinical interpretation.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Ro 19-5247 is the active metabolite of the oral cephalosporin Ro 19-5248 (T-2588).
- Comparative in vitro activity of oral antibiotics is crucial for guiding clinical treatment decisions.
Purpose of the Study:
- To compare the in vitro antibacterial activity of Ro 19-5247 against a panel of oral antibiotics.
- To establish interpretive criteria for in vitro susceptibility testing of Ro 19-5247.
Main Methods:
- In vitro susceptibility testing of Ro 19-5247 and five other oral agents against 331 bacterial strains.
- Regression analysis to correlate zone sizes and minimum inhibitory concentrations (MICs) for disk diffusion testing.
Main Results:
- Ro 19-5247 exhibited greater activity than amoxicillin, amoxicillin-clavulanate, cefaclor, cefuroxime, and cephalexin against Enterobacteriaceae.
- Amoxicillin and amoxicillin-clavulanate were most active against staphylococci.
- Ro 19-5247, amoxicillin-clavulanate, amoxicillin, and cefuroxime showed similar activity against nonenterococcal streptococci.
- Limited activity was observed against nonfermentative gram-negative bacteria and Streptococcus (Enterococcus) faecalis.
Conclusions:
- Ro 19-5247 possesses significant in vitro activity against Enterobacteriaceae.
- Tentative breakpoints for Ro 19-5247 disk diffusion susceptibility testing were proposed based on regression analysis.