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Wave Parameters01:10

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The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
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It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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Related Experiment Video

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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
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Masticatory function parameters in patients with removable dental prosthesis.

Alexandra Melania Oncescu Moraru1, Cristina Teodora Preoteasa2, Elena Preoteasa1

  • 1Department of Complete Denture, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Journal of Medicine and Life
|May 25, 2019
PubMed
Summary

Masticatory efficiency varies with food type and patient status. Dental prostheses and remaining teeth significantly improve chewing function, highlighting their importance for oral health.

Keywords:
carrot testchewingdentureedentulismfoodmastication

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Area of Science:

  • Dentistry
  • Biomedical Engineering
  • Nutrition Science

Background:

  • Masticatory efficiency is crucial for nutrient absorption and overall health.
  • Removable dental prostheses can impact chewing function.
  • Systemic, oral, and prosthetic factors influence mastication.

Purpose of the Study:

  • To evaluate masticatory efficiency in patients with removable dental prostheses.
  • To analyze the influence of systemic, oral, and prosthetic states on chewing.
  • To compare masticatory performance with different food consistencies.

Main Methods:

  • Convenience sample of patients aged 45+ with removable prostheses.
  • Chewing of digestive biscuits, apple, and carrot until swallowing.
  • Measurement of chewing time, cycle count, duration, and frequency.
  • Statistical analysis of masticatory parameters based on food and patient status.

Main Results:

  • Masticatory parameters differed significantly based on food type (e.g., carrot vs. apple) due to consistency, wetting, and adherence.
  • Chewing time and cycle count positively correlated across all foods.
  • Complete dentures, overdentures, altered general status, and advanced age were associated with increased chewing time and cycles.

Conclusions:

  • Chewing time and effort are influenced by individual characteristics, food properties, and prosthetic status.
  • The number of residual teeth and type of prosthetic rehabilitation are key indicators of improved masticatory efficiency.
  • Prosthetic rehabilitation plays a vital role in optimizing masticatory function.