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Related Experiment Video

Updated: Jan 24, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Quantifying microstructural changes in retinitis pigmentosa using spectral domain - optical coherence tomography.

B Poornachandra1, Aruj K Khurana1, Preethi Sridharan1

  • 11Department of Vitreo Retina, Narayana Nethralaya Eye Institute, Bangalore, India.

Eye and Vision (London, England)
|May 25, 2019
PubMed
Summary

Spectral Domain-Optical Coherence Tomography (SD-OCT) reveals that the Foveal Outer Segment Pigment Epithelial Thickness to Photoreceptor Outer Segment Length ratio (FPR) can predict visual acuity in retinitis pigmentosa (RP) patients. This microstructural analysis aids in monitoring central retinal disease progression.

Keywords:
Ellipsoid zone (EZ)FOSPET-PROS ratio (FPR)Foveal outer segment pigment epithelial thickness (FOSPET)Photoreceptor outer segment length (PROS)Retinitis Pigmentosa

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Retinitis pigmentosa (RP) patients typically experience reduced peripheral vision, making central vision critical for daily function.
  • Central visual acuity relies on the health of macular photoreceptors.
  • Identifying early structural changes preceding vision loss in RP is crucial for management.

Purpose of the Study:

  • To correlate Spectral Domain-Optical Coherence Tomography (SD-OCT) findings with visual acuity in patients diagnosed with typical retinitis pigmentosa (RP).

Main Methods:

  • A retrospective observational study involved 224 eyes from 113 RP patients.
  • SD-OCT imaging was utilized to measure central retinal thickness (CRT), photoreceptor outer segment length (PROS), and foveal outer segment pigment epithelial thickness (FOSPET).
  • A novel FOSPET-PROS ratio (FPR) was calculated and correlated with corrected distance visual acuity (CDVA) using linear regression.

Main Results:

  • The study included 113 RP patients (71 males, 42 females) with a mean age of 35.4 years.
  • Mean CDVA was 0.33 ± 0.25 logMAR.
  • CRT and FPR showed significant correlation with CDVA (r = -0.139, p = 0.048 and r = 0.842, p < 0.001, respectively).
  • FOSPET and PROS did not significantly correlate with CDVA independently of FPR.

Conclusions:

  • Retinal microstructural changes observed via SD-OCT, particularly the FPR, serve as a reliable surrogate marker.
  • These markers can effectively monitor disease progression within the central retina of patients with degenerative retinal diseases like RP.