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Updated: Jan 24, 2026

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

10.3K

Microbe Profile: Listeria monocytogenes: a paradigm among intracellular bacterial pathogens

Javier Pizarro-Cerdá1, Pascale Cossart2

  • 1Yersinia Research Unit, Department of Microbiology, Institut Pasteur - 75015 Paris, France.

Microbiology (Reading, England)
|May 25, 2019
PubMed

Insights

Listeria monocytogenes is a food-borne pathogen causing listeriosis. This bacterium invades host cells and evades immune responses, making it a model for intracellular parasitism.

Area of Science:

  • Microbiology
  • Pathogen Research
  • Infectious Diseases

Background:

  • Listeria monocytogenes is a significant food-borne pathogen responsible for listeriosis.
  • Listeriosis presents with varied symptoms, including gastroenteritis, abortion, meningitis, and fatal bacteremia, particularly in vulnerable populations.

Observation:

  • L. monocytogenes exhibits remarkable ability to breach human physiological barriers.
  • The pathogen efficiently enters diverse epithelial cells and replicates intracellularly.

Findings:

  • The bacterium's pathogenesis is linked to its capacity for barrier traversal and intracellular proliferation.
  • L. monocytogenes effectively evades host immune system responses.

Implications:

  • Understanding L. monocytogenes' intracellular lifestyle provides insights into host-pathogen interactions.
  • This pathogen serves as a key model organism for studying intracellular bacterial pathogenesis.
Keywords:
actin cytoskeletonlisteriolysin S

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