Practical Catalytic Cleavage of C(sp3 )-C(sp3 ) Bonds in Amines
Wu Li1, Weiping Liu1, David K Leonard1
1Leibniz-Institut für Katalyse e.V. an der, Universität Rostock, Albert-Einstein Straße 29a, 18059, Rostock, Germany.
Abstract:
The selective cleavage of thermodynamically stable C(sp3 )-C(sp3 ) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα -Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules.
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