Related Experiment Video
Updated: Jan 24, 2026
11:02
Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
Published on: October 18, 2013
19.9K
Genetic alterations and their clinical implications in DLBCL
Yi Miao1, L Jeffrey Medeiros1, Yong Li2
1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nature Reviews. Clinical Oncology
|May 26, 2019
Summary
Diffuse large B cell lymphoma (DLBCL) exhibits significant genetic diversity, impacting patient outcomes. Understanding these genetic alterations is key to improving DLBCL classification, prognosis, and targeted therapies.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Diffuse large B cell lymphoma (DLBCL) is a heterogeneous lymphoid malignancy.
- Genetic alterations significantly influence DLBCL's clinical course and treatment response.
Purpose of the Study:
- To review the genetic landscape of DLBCL.
- To elucidate the role of genetic alterations in DLBCL pathogenesis, classification, and therapeutic targeting.
Main Methods:
- Review of high-throughput genome sequencing and whole-exome sequencing studies.
- Analysis of genetic alterations in DLBCL and their impact on signaling pathways.
Main Results:
- Numerous genetic alterations identified in DLBCL, affecting B cell differentiation, signaling, NF-κB pathway, apoptosis, and epigenetic regulation.
- These aberrations are implicated in disease development and progression.
Conclusions:
- Elaborating on DLBCL genetics enhances understanding of pathogenesis and disease classification.
- Genetic insights provide targets for improved prognostication and novel therapeutic strategies.
More Related Videos
Related Concept Videos
02:16Genetics of Speciation
21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K
00:49What is Genetic Engineering?
79.9K
Overview
79.9K
01:30Alterations in Respiration II
1.7K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.7K
01:06Altered States of Awareness
1.0K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.0K
01:30Alterations in Blood Pressure
2.1K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.1K
01:25What is Population Genetics?
64.5K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.5K