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Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Bone Marrow Adiposity: Basic and Clinical Implications.

Zachary L Sebo^1,2, Elizabeth Rendina-Ruedy³, Gene P Ables⁴

¹Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.

Endocrine Reviews

|May 26, 2019

Summary

This summary is machine-generated.

Marrow adipose tissue (MAT), composed of adipocytes in bone marrow, is a distinct fat depot crucial for regulating the bone marrow microenvironment and whole-body metabolism. Recent advancements enable detailed study of MAT's origins, functions, and roles in human health and disease.

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Bone Marrow-derived Macrophage Production

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

Area of Science:

Endocrinology
Metabolism
Bone Biology

Background:

Adipocytes in mammalian bone marrow (BM) were historically overlooked.
Recent technological advances allow detailed examination of these cells.
Marrow adipocytes are distinct from other fat cell types.

Purpose of the Study:

To review the developmental origins and physiological functions of marrow adipose tissue (MAT).
To discuss factors influencing MAT accumulation and loss.
To explore MAT's regulatory roles in the BM and its implications for human health.

Main Methods:

Review of recent literature on mouse transgenics and imaging techniques.
Histological and functional analyses of marrow adipocytes.
Exploration of signaling pathways regulating MAT.

Main Results:

Marrow adipocytes are critical regulators of the BM microenvironment.
MAT plays a significant role in whole-body metabolism.
Marrow adipocytes are anatomically and functionally distinct from other fat depots.

Conclusions:

Marrow adipose tissue is a unique and important endocrine organ.
Understanding MAT is vital for comprehending bone marrow function and systemic metabolism.
MAT has potential implications in human physiology and disease pathogenesis.