Parameter estimation in a minimal model of cardio-pulmonary interactions

Mechanical ventilation is a widely used breathing support for patients in intensive care. Its effects on the respiratory and cardiovascular systems are complex and difficult to predict. This work first presents a minimal mathematical model representing the mechanics of both systems and their interaction, in terms of flows, pressures and volumes. The aim of this model is to get insight on the two systems' status when mechanical ventilation settings, such as positive end-expiratory pressure, are changing. The parameters of the model represent cardiac elastances and vessel compliances and resistances. As a second step, these parameters are estimated from 16 experimental datasets. The data come from three pig experiments reproducing intensive care conditions, where a large range of positive end-expiratory pressures was imposed by the mechanical ventilator. The data used for parameter estimation is limited to information available in the intensive care unit, such as stroke volume, central venous pressure and systemic arterial pressure. The model is able to satisfactorily reproduce this experimental data, with mean relative errors ranging from 1 to 26%. The model also reproduces the dynamics of the cardio-vascular and respiratory systems, and their interaction. By looking at the estimated parameter values, one can quantitatively track how the two coupled systems mechanically react to changes in external conditions imposed by the ventilator. This work thus allows real-time, model-based management of ventilator settings.