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Updated: Jan 24, 2026

Identification of Fatty Acids in Bacillus cereus
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Empty Sella in the Making.

Lora Stanka Kirigin Biloš1, Ivan Kruljac1, Jelena Marinković Radošević1

  • 1Department of Endocrinology, Diabetology and Metabolic Diseases "Mladen Sekso", University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.

World Neurosurgery
|May 26, 2019
PubMed
Summary

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Pituitary apoplexy, a condition involving pituitary tumors, can often be managed conservatively. This approach, focusing on hormonal treatment and monitoring, can lead to significant tumor reduction and favorable outcomes.

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Pituitary apoplexy results from ischemic necrosis and hemorrhage in pituitary tumors.
  • Historically considered a neurosurgical emergency, conservative management is increasingly supported.
  • Spontaneous remission is rare in nonfunctioning pituitary tumors.

Observation:

  • A case of pituitary apoplexy in a nonfunctioning pituitary macroadenoma managed conservatively over two years.
  • The patient received hormonal treatment for hypopituitarism.
  • Serial neuroimaging revealed substantial tumor volume reduction and near-complete resolution, leading to a partial empty sella.

Findings:

  • Conservative management of pituitary apoplexy, particularly in nonfunctioning adenomas, can result in significant tumor shrinkage.
Keywords:
ApoplexyConservativeEmpty sellaNonfunctioning pituitary adenomaSpontaneous remission

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  • Hormonal therapy is crucial for managing associated hypopituitarism.
  • Complete resolution and partial empty sella formation were observed in the presented case.

    • Implications:

    • A select group of pituitary apoplexy patients, without altered consciousness and with mild/nonprogressive ophthalmologic deficits, may benefit from conservative management.
    • Lifelong monitoring by a multidisciplinary pituitary team is essential for these patients.
    • This case highlights the potential for conservative strategies in managing pituitary apoplexy, challenging the traditional emergency surgical approach.