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Predicting candidemia in the internal medicine wards: a comparison with gram-negative bacteremia-a retrospectives

Alaa Atamna1, Noa Eliakim-Raz2, Jenan Mohana3

  • 1Infectious Disease Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Diagnostic Microbiology and Infectious Disease
|May 27, 2019
PubMed
Abstract

Insights

Identifying underweight patients, those with prior cephalosporin use, and central venous catheters (CVCs) can help predict candidemia in internal medicine wards. This aids in early diagnosis and treatment of this serious bloodstream infection.

Area of Science:

  • Infectious Diseases
  • Internal Medicine
  • Clinical Microbiology

Background:

  • Risk factors for candidemia in internal medicine wards (IMW) are not well understood.
  • Identifying these factors is crucial for timely diagnosis and treatment of candidemia.

Purpose of the Study:

  • To identify predictors of candidemia in IMW.
  • To compare these predictors with those of gram-negative bacteremia (GNB) in the same setting.

Main Methods:

  • Retrospective study of patients with candidemia in IMW from 2007-2016.
  • Comparison with a cohort of patients diagnosed with GNB.
  • Analysis of patient demographics, comorbidities, and clinical characteristics.

Main Results:

  • Candidemia patients were younger and had a lower body mass index compared to GNB patients.
  • Multivariate analysis revealed underweight status, prior cephalosporin use, and central venous catheters (CVCs) as significant predictors of candidemia.
  • Odds ratios indicated a significant association between these factors and candidemia.

Conclusions:

  • Underweight status, recent cephalosporin exposure, and CVCs are significant predictors of candidemia in IMW.
  • These findings can assist in identifying high-risk patients for candidemia.
  • Early recognition may lead to prompt and appropriate empirical treatment.
Keywords:
CandidemiaMedical wardsPredictors

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