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Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
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Triplet Fusion Upconversion Nanocapsule Synthesis
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Chitosan based self-assembled nanocapsules as antibacterial agent.

Sabrina Belbekhouche1, Noureddine Bousserrhine2, Vanessa Alphonse2

  • 1Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS-Université Paris-Est Créteil Val-de-Marne, 2 rue Henri Dunant, 94320 Thiais, France.

Colloids and Surfaces. B, Biointerfaces
|May 27, 2019
PubMed
Summary

Researchers developed new biodegradable nanocapsules using chitosan and alginate. These novel antibacterial materials effectively inhibit bacterial growth and offer a promising alternative for microbial control without harmful byproducts.

Keywords:
AgentAntibacterialChitosanGold nanoparticleLayer-by-layer assemblyNanocapsuleParticle-templatedPathogenic bacteriaPolysaccharide

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • Developing effective antibacterial systems without harmful byproducts is a significant challenge.
  • Novel technologies are needed for efficient disinfection and microbial control.

Purpose of the Study:

  • To create biodegradable and biocompatible polymeric nanocapsules for potential antibiotic therapy.
  • To investigate the antibacterial efficacy of these nanocapsules against Staphylococcus aureus and Escherichia coli.

Main Methods:

  • Fabrication of nanocapsules via self-assembly of chitosan and alginate onto gold nanoparticles.
  • Removal of gold core using cyanide-assisted hydrolysis to form hollow nanocapsules.
  • Evaluation of antibacterial activity through bacterial growth inhibition assays and acridine orange staining.

Main Results:

  • Successfully synthesized well-ordered multilayer films of chitosan and alginate on gold nanoparticles.
  • Demonstrated significant inhibition of Staphylococcus aureus and Escherichia coli growth by the nanocapsules.
  • Confirmed the bactericidal effect of chitosan-based nanocapsules using acridine orange staining.

Conclusions:

  • Chitosan/alginate nanocapsules are effective antibacterial materials.
  • These nanocapsules offer a complementary approach to traditional nanoparticles for antibacterial applications.
  • The developed system shows potential for safe and efficient microbial control.