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Factors associated with thyroid dysfunction in children with newly diagnosed type 1 diabetes mellitus

Weixia Yang1, Feifei Sheng2

  • 1Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, China - ywx20061332@163.com.

Minerva Pediatrics
|May 28, 2019
PubMed

Insights

Thyroid dysfunction in children with type 1 diabetes is linked to family history and autoimmunity. Regular thyroid screening is recommended for these patients.

Area of Science:

  • Pediatric Endocrinology
  • Diabetology
  • Thyroidology

Background:

  • Type 1 diabetes mellitus (T1DM) is an autoimmune condition.
  • Thyroid dysfunction (TD) is a common comorbidity in T1DM patients.
  • Investigating TD factors in pediatric T1DM is crucial for management.

Purpose of the Study:

  • To identify factors associated with thyroid dysfunction in children with T1DM.
  • To assess the prevalence of different types of thyroid dysfunction.
  • To explore the relationship between autoimmunity, family history, and metabolic stress in TD.

Main Methods:

  • Eighty-seven children with T1DM were assessed.
  • Clinical profiles, pancreatic, and thyroid antibodies were evaluated.
  • Thyroid function tests were performed at baseline and after 10 days of treatment.

Main Results:

  • Thyroid dysfunction was observed in 14.9% of patients post-metabolic correction.
  • Subclinical hypothyroidism was most prevalent (10.3%).
  • Positive pancreatic and thyroid antibodies, and a family history of TD were significantly associated with TD (P<0.01, P<0.05).
  • Thyroid hormone levels normalized after treatment in children with diabetic ketoacidosis (DKA).

Conclusions:

  • Thyroid dysfunction in T1DM is associated with family factors, autoimmunity, and metabolic stress.
  • Early detection and regular thyroid screening are essential for children with T1DM.
  • Understanding these associations can guide proactive management strategies.
Abstract

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