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Updated: Jan 24, 2026
16:26
Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport
Published on: June 28, 2014
43.2K
Advances in Microfluidic Blood-Brain Barrier (BBB) Models.
Arianna Oddo1, Bo Peng2, Ziqiu Tong1
1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Trends in Biotechnology
|May 28, 2019
Summary
Microfluidic blood-brain barrier (BBB) models offer new ways to study brain disorders and test drugs. These advanced in vitro systems mimic the brain
Area of Science:
- Neuroscience and biomedical engineering
- Development of advanced in vitro models for neurological research
Background:
- Current therapeutic options for neurological disorders are limited due to the brain's complex architecture.
- Drug delivery to the brain is challenging, hindering treatment efficacy.
- In vitro models are needed to better understand brain diseases and screen potential treatments.
Purpose of the Study:
- To review recent advancements in microfluidic blood-brain barrier (BBB)-on-chip devices.
- To discuss the validation steps necessary for strengthening the application of these models.
- To highlight the potential of BBB-on-chip systems in neurological research and drug discovery.
Main Methods:
- Review of recent scientific literature on microfluidic BBB models.
- Analysis of current technological advancements in organ-on-chip systems.
- Examination of validation strategies for in vitro BBB models.
Main Results:
- Microfluidic technology enables the creation of in vitro platforms that mimic in vivo microenvironments.
- BBB-on-chip models offer a promising approach for studying neurodegenerative diseases.
- These models facilitate high-throughput drug screening for brain-related therapeutics.
Conclusions:
- Microfluidic BBB-on-chip devices represent a significant advancement in neurological research.
- Further validation is crucial for the widespread adoption and reliability of these models.
- BBB-on-chip technology holds great potential for accelerating the development of treatments for neurological disorders.
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