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Updated: Jan 24, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
When fat goes down, prostate cancer is on the ropes
Giorgia Zadra1,2, Massimo Loda1,3,4
1Dana-Farber Cancer Institute, Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Abstract:
Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor signaling. Our study uncovers the interplay between lipogenesis and androgen receptor and proposes novel combinatorial therapeutic approaches.
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