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Updated: Jan 24, 2026

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Circular RNA circMAN2B2 facilitates glioma progression by regulating the miR-1205/S100A8 axis
Jinsheng Xiong1, Tianyao Wang2, Haitao Tang3
1Department of Neurosurgery, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China.
Abstract:
The aim of this study was to research the mechanism of circMAN2B2 in the development of glioma. In our study, we found that circMAN2B2 has a higher expression in glioma tissues and cells, which was negatively related to the overall survival of glioma patients. The cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine labeling assay, transwell assay, and the nude mice assay indicated that knockdown of circMAN2B2 inhibited the cell proliferation, invasion, migration and decreased tumor size. In terms of mechanism, knockdown of circMAN2B2 increased the expression of miR-1205. Moreover, circMAN2B2 regulated S100A8 expression by inhibiting miR-1205. We also showed that knockdown of S100A8 inhibited cell proliferation, invasion, and migration. Increasing S100A8 expression rescued the effect of si-circMAN2B2. In conclusion, circMAN2B2 could improve cell proliferation, invasion, and migration of the glioma by inhibiting miR-1205 and promoting the expression of S100A8.
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