Fosfomycin in infections caused by multidrug-resistant Gram-negative pathogens
J Ruiz Ramos, M Salavert Lletí1
1Miguel Salavert Lletí. Unidad de Enfermedades Infecciosas. Hospital Universitario y Politécnico La Fe, Valencia. Av. Fernando Abril Martorell, nº 106; Valencia 46026. Spain. Salavert_mig@gva.es.
Summary
Fosfomycin, an older antibiotic, shows promise for treating complex infections caused by multidrug-resistant Gram-negative bacteria. Its reassessment offers a viable option amid rising antibiotic resistance and limited new drug development.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Rising antibiotic resistance necessitates alternative treatment strategies.
- Limited development of new antimicrobial drugs makes older antibiotics valuable.
- Fosfomycin, previously used for urinary tract infections, is gaining attention.
Purpose of the Study:
- To review the potential of fosfomycin for treating infections beyond the urinary tract.
- To evaluate fosfomycin's efficacy against multidrug-resistant Gram-negative bacteria.
Main Methods:
- Literature review of key available data on fosfomycin.
- Analysis of resistance patterns in Gram-negative bacteria.
- Assessment of fosfomycin's role in treating complex infections.
Main Results:
- Fosfomycin exhibits bactericidal activity.
- Emerging resistance patterns in Gram-negative bacteria are noted.
- Fosfomycin shows potential for treating infections caused by resistant pathogens.
Conclusions:
- Fosfomycin is a potential treatment option for multidrug-resistant Gram-negative bacterial infections.
- Expanding fosfomycin use beyond urinary tract infections is a promising strategy.
- Further research is warranted to explore its broader clinical applications.
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