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Updated: Jul 2, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Antibiotic stewardship programs in the Spanish emergency services: PROA-URG Study].
J Ruiz Ramos1, A Suárez-Lledó Grande, M R Santolaya Perrín
1Jesús Ruiz Ramos, Servicio de Farmacia. Hospital Santa Creu y San Pau, Barcelona. C/San Quintín 89, 08025 Barcelona, Spain. jrzrms@gmail.com.
Antimicrobial stewardship programs (ASP) are present in emergency departments, but knowledge of antimicrobial use and resistance patterns remains limited. Future efforts should focus on enhancing data collection and reporting within these critical care units.
Area of Science:
- Healthcare Management
- Infectious Diseases
- Clinical Pharmacy
Background:
- Antimicrobial stewardship programs (ASP) are crucial for optimizing antimicrobial use in healthcare systems.
- Information regarding ASP implementation and key performance indicators in emergency departments (EDs) is limited.
- This study addresses the gap in understanding ASP practices within EDs.
Purpose of the Study:
- To assess the extent of ASP implementation in emergency departments.
- To evaluate the patterns of antimicrobial utilization in these specific units.
- To identify challenges and areas for improvement in ED-based ASP.
Main Methods:
- A multicenter retrospective study design was employed.
- A survey questionnaire comprising 21 items was distributed to emergency pharmacist working groups.
- Data were collected and analyzed from a team of specialists including pharmacists, emergency physicians, infectious disease specialists, and microbiologists.
Main Results:
- Eighteen hospitals participated, with 77.8% having dedicated ASP managers.
- Antimicrobial consumption, measured in DDD per 1000 admissions, showed significant variability (median: 100.4).
- Limited reporting on resistance profiles and variability in treatment adequacy for common infections were observed.
Conclusions:
- While ASP presence and educational activities are common in emergency services, comprehensive knowledge of antimicrobial use and resistance is lacking.
- There is a need to improve the availability and dissemination of information regarding ASP outcomes in emergency departments.
- Future initiatives should prioritize enhancing data transparency and actionable insights from ASP in ED settings.
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