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Related Experiment Video

Updated: Jan 24, 2026

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Clinical Symptom Profiles After Mild-Moderate Stroke.

Irene L Katzan1,2, Andrew Schuster1, Mark Bain2

  • 11 Neurological Institute Center for Outcomes Research & Evaluation Cleveland Clinic Cleveland OH.

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|May 28, 2019
PubMed
Summary

Stroke patients exhibit diverse clinical profiles impacting health-related quality of life (hrQoL). Identifying these patient groups can guide personalized interventions to enhance recovery and well-being after stroke.

Keywords:
outcomepatient‐reported outcomestrokesymptom cluster

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Health Outcomes Research

Background:

  • Stroke heterogeneity leads to varied health-related quality of life (hrQoL) outcomes.
  • Tailored interventions require identification of distinct clinical profiles in stroke survivors.

Purpose of the Study:

  • To identify and characterize distinct clinical profiles among patients with recent stroke.
  • To explore the relationship between these profiles and health-related quality of life (hrQoL).

Main Methods:

  • Observational study of 496 patients with ischemic stroke or intracerebral hemorrhage.
  • Utilized Patient-Reported Outcome Measurement Information System (PROMIS) tools for symptom assessment.
  • Latent profile analysis identified groups based on PROMIS domains and modified Rankin Scale (mRS) scores.

Main Results:

  • Five distinct clinical profiles were identified among stroke patients.
  • Profiles varied in symptom severity across domains (pain, depression, cognition, fatigue, social, physical function).
  • Similar modified Rankin Scale (mRS) scores did not always correlate with similar hrQoL profiles.

Conclusions:

  • Stroke patients present with unique clinical symptom profiles, irrespective of clinician-assessed disability.
  • These symptom profiles offer a nuanced understanding of post-stroke outcomes.
  • Profile identification can facilitate targeted interventions to improve patient hrQoL.