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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

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Circulating microRNAs to predict heart failure after acute myocardial infarction in women

Torkia Lalem1, Yvan Devaux1

  • 1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg.

Clinical Biochemistry
|May 28, 2019
PubMed

Insights

Sex-specific microRNAs show promise for predicting heart failure after myocardial infarction. Circulating microRNAs may offer improved risk stratification by accounting for biological differences between males and females.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Left ventricular remodeling post-myocardial infarction (MI) impairs cardiac function and elevates heart failure risk.
  • Current biomarkers for predicting heart failure after MI lack precision, necessitating improved risk stratification strategies.
  • Biological responses to ischemic stress differ between sexes, impacting cardiac outcomes and suggesting the need for sex-specific biomarkers.

Purpose of the Study:

  • To review the potential of circulating microRNAs (miRNAs) as biomarkers for predicting heart failure after acute myocardial infarction (AMI).
  • To explore the sex-specific expression and modulation of miRNAs, and their relevance in cardiovascular disease.
  • To discuss how sex-specific miRNA profiles could enhance risk stratification for heart failure post-AMI.

Main Methods:

  • Literature review focusing on circulating microRNAs, left ventricular remodeling, acute myocardial infarction, and heart failure.
  • Analysis of studies investigating miRNA expression, regulation by sex hormones, and X-chromosome inactivation.
  • Synthesis of evidence on the association between circulating miRNAs and adverse cardiac events post-MI.

Main Results:

  • MicroRNAs are implicated in cardiac remodeling pathways and are found circulating in the bloodstream.
  • Circulating miRNAs have demonstrated potential as predictive biomarkers for heart failure following AMI.
  • Evidence suggests that multiple miRNAs exhibit sex-specific expression patterns, influenced by hormonal factors and chromosomal location.

Conclusions:

  • Circulating microRNAs represent a promising avenue for developing novel biomarkers for heart failure prediction post-MI.
  • Sex-specific miRNA analysis may significantly improve the accuracy of risk stratification in patients with AMI.
  • Further research into sex-specific miRNA biomarkers is warranted to optimize cardiovascular risk assessment and patient management.

Keywords:
Acute myocardial infarctionBiomarkerHeart failureLeft ventricular remodelingSexmicroRNA

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