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Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease

Danxia Qin1, Han Zhang2, Jiehua Wang1

  • 1Inpatient Department 7th floor District 6, Dongjie Branch of Quanzhou 1st Hospital, Quanzhou 1st Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.

BMC Medical Genomics
|May 29, 2019
PubMed
Abstract

Insights

Histamine H4 receptor gene variations may increase Meniere

Area of Science:

  • Immunology
  • Genetics
  • Otolaryngology

Background:

  • The immune system's role in Meniere's disease (MD) pathophysiology is suspected but not well-understood.
  • Histamine H4 receptors are highly expressed in immune cells, suggesting a potential link to MD.
  • Investigating histamine H4 receptor gene polymorphisms could reveal contributions to MD risk.

Purpose of the Study:

  • To test the hypothesis that histamine H4 receptor gene polymorphisms contribute to Meniere's disease risk.
  • To explore the association between a specific HRH4 gene polymorphism (rs77485247) and MD.
  • To investigate correlations between this polymorphism, vertigo symptoms, and proinflammatory cytokine levels in MD patients.

Main Methods:

  • Enrolled patients with definite Meniere's disease (MD) and a control group without vestibular disorders.
  • Selected a single nucleotide polymorphism (SNP), rs77485247, in the histamine H4 receptor (HRH4) gene.
  • Conducted exploratory analysis of correlations between the rs77485247 polymorphism, vertigo, and cytokine levels (IL-1β, TNF-α) in peripheral blood mononuclear cells (PBMCs).

Main Results:

  • The HRH4 rs77485247 polymorphism showed a potential association with Meniere's disease risk.
  • Patients with MD exhibited increased basal levels of proinflammatory cytokines (IL-1β, TNF-α) in PBMCs compared to controls.
  • Elevated cytokine levels were more pronounced in MD patients carrying the 'A' allele of the rs77485247 polymorphism.

Conclusions:

  • The HRH4 rs77485247 polymorphism may play a role in Meniere's disease pathogenesis.
  • This polymorphism might mediate the regulation of proinflammatory cytokines implicated in MD.
  • Further research is warranted to elucidate the specific mechanisms linking HRH4 genetics to MD.
Keywords:
Histamine H4 receptorsMeniere’s diseasePolymorphismProinflammatory cytokines

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