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B Cribier1

  • 1Hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, BP 426, 67091 Strasbourg, Cedex, France.

Annales De Dermatologie Et De Venereologie
|May 29, 2019
PubMed
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Actinic keratoses are pre-cancerous skin lesions common in sun-exposed areas. Early diagnosis and biopsy are crucial for differentiating them from squamous cell carcinoma, preventing progression.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Actinic keratoses (AKs) are epidermal preneoplastic lesions found in sun-exposed areas.
  • They present as keratosis with erythema and potential induration, often occurring in fields of cancerization.
  • Diagnosis is typically clinical, but biopsy is essential for atypical or recurrent lesions.

Purpose of the Study:

  • To review the clinicopathological features of actinic keratoses.
  • To highlight the diagnostic challenges and the importance of biopsy.
  • To discuss the potential for malignant transformation into squamous cell carcinoma.

Main Methods:

  • Review of histopathological findings in actinic keratoses.
  • Description of common subtypes including hypertrophic, atrophic, pigmented, and lichenoid variants.
Keywords:
Actinic keratosisCarcinome épidermoïdeDermatopathologieDermatopathologyDysplasie épidermiqueEpidermal dysplasiaKératose actiniqueSquamous cell carcinoma

Related Experiment Videos

  • Discussion of diagnostic criteria and differential diagnosis, including the role of dermatoscopy.

    • Main Results:

    • Histopathology reveals epidermal basal layer dysplasia with specific nuclear and cytoplasmic changes.
    • Key differential diagnosis is squamous cell carcinoma, characterized by invasive atypical cells.
    • Dermatoscopy aids in decision-making for biopsy and differential diagnosis.

    Conclusions:

    • Actinic keratoses require careful clinical and histopathological evaluation due to their pre-cancerous nature.
    • Timely biopsy is critical for accurate diagnosis and to rule out squamous cell carcinoma.
    • Non-invasive imaging like dermatoscopy can support clinical decision-making.